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Measurement of Serum Calprotectin in Stable Patients Predicts Exacerbation and Lung Function Decline in Cystic Fibrosis.

Reid PA, McAllister DA, Boyd AC, Innes JA, Porteous D, Greening AP, Gray RD

American Journal of Respiratory and Critical Care Medicine

Am J Respir Crit Care Med. 2015 Jan 15;191(2):233-236.

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Clinical tests that predict clinical outcomes in cystic fibrosis (CF) such as exacerbation risk and lung function decline are lacking.

Calprotectin (MRP8/14, S100A8/A9) is an abundant neutrophil protein found in bronchoalveolar lavage fluid (1), sputum (2), and serum of patients with CF (3).

We have demonstrated that serum calprotectin changes with treatment of exacerbation, and predicts time to re-exacerbation .

We hypothesized that stable patients with higher serum calprotectin at baseline would exacerbate sooner and have more rapid lung function decline.

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Alton EW et al. Gene Therapy (2013) A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis.
Alton EW et al. Thorax (2013) Sputum and serum calprotectin are useful biomarkers during CF exacerbation.
Gray RD et al. Journal Of Cystic Fibrosis : Official Journal Of The European Cystic Fibrosis Society (2010) Revisiting the mouse lung model for CF.
Boyd AC et al. Gene Therapy (2004) The effects of plasmid copy number and sequence context upon transfection efficiency.
Walker WE et al. Journal Of Controlled Release : Official Journal Of The Controlled Release Society (2003) Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination.
Boyd AC et al. The Journal Of Gene Medicine (2000)